Metabolomics data complemented drug use information in epidemiological databases: pilot study of potential kidney donors

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چکیده

ObjectiveThe objective of this study was to investigate whether clinical metabolomics, which is increasingly applied in population-based and epidemiological studies, can be used provide analytical evidence exposures, such information useful strengthen and/or complement corresponding database entries, taking drug use as an example.Study design settingLiquid chromatography-mass spectrometry (LC-MS) metabolomics analyses were performed on urine from 100 randomly-selected control subjects (50% females) the TransplantLines Food Nutrition Biobank Cohort Study (NCT identifier ‘NCT02811835’), drugs identified through spectral library searching targeted signal extraction.ResultsIn 83 for whom available, 22 expected 26 unexpected prescription-only identified, while 28 remained undetected. In addition, 7 found 17 unavailable, 58 over-the-counter all subjects.ConclusionMolecular many could retrieved LC-MS data, databases given that considerable discrepancies between analytically-identified listed available database.

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ژورنال

عنوان ژورنال: Journal of Clinical Epidemiology

سال: 2021

ISSN: ['1878-5921', '0895-4356']

DOI: https://doi.org/10.1016/j.jclinepi.2021.02.008