Metabolomics data complemented drug use information in epidemiological databases: pilot study of potential kidney donors
نویسندگان
چکیده
ObjectiveThe objective of this study was to investigate whether clinical metabolomics, which is increasingly applied in population-based and epidemiological studies, can be used provide analytical evidence exposures, such information useful strengthen and/or complement corresponding database entries, taking drug use as an example.Study design settingLiquid chromatography-mass spectrometry (LC-MS) metabolomics analyses were performed on urine from 100 randomly-selected control subjects (50% females) the TransplantLines Food Nutrition Biobank Cohort Study (NCT identifier ‘NCT02811835’), drugs identified through spectral library searching targeted signal extraction.ResultsIn 83 for whom available, 22 expected 26 unexpected prescription-only identified, while 28 remained undetected. In addition, 7 found 17 unavailable, 58 over-the-counter all subjects.ConclusionMolecular many could retrieved LC-MS data, databases given that considerable discrepancies between analytically-identified listed available database.
منابع مشابه
epidemiological study of oral and pharyngeal cancers in kermanshah province from march 1993 to march 2006
چکیده ندارد.
15 صفحه اولUse of a pilot drug information centre.
INTRODUCTION Provision of access to drug information by prescribers and other health care professionals is important in pharmacotherapy. At the time of this study there was very scanty literature in this area from Africa. OBJECTIVE To assess use of a pilot drug information centre (DIC) which was set up in a department of Pharmacology and Therapeutics in a university teaching hospital in Ugand...
متن کاملComparison of Bibliographic Databases in Retrieving Information on Telemedicine
Background & Aims: Some of the main questions which can be of importance for those researchers who intend to perform a systematic review in a field of science are: ‘What databases should I use for my review?’; ‘Do all these databases have the same value?’; and ‘Which sourcesretrieved the highest of relevant references?’. The main aim of this work was the identification of the best database for ...
متن کاملAdjunctive use of electroconvulsive therapy in patients with Lennox-Gastaut syndrome and drug-resistant epilepsy: A pilot study
Background: Lennox-Gastaut syndrome (LGS) is an epileptic encephalopathy, characterized by drug-resistant multiple seizure types. The aim of this study was to determine if the adjunctive use of electroconvulsive therapy (ECT) in patients with LGS and drug-resistant epilepsy is efficacious in decreasing their seizure frequency and also to investigate its safety and tolerability. Method...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Epidemiology
سال: 2021
ISSN: ['1878-5921', '0895-4356']
DOI: https://doi.org/10.1016/j.jclinepi.2021.02.008